ADME studies are creating new drugs throughout the world. The drug discovery scenario has changed over the years with new developments taking place in terms of technology. Computer aided drug designing has added more speed and precision to the drug discovery process. Pharmaceuticals now have a reliable way of checking out lead candidates with the use of state-of-the-art instrumentation and computer software.
Several companies are making new alliances and partnerships to keep producing optimized and new drugs for a wide range of diseases such as cancer, Alzheimer’s disease, and heart diseases. Various chemical compounds influence human response in a negative or positive way. The nutritional state and concomitant drugs play a significant role in absorption and distribution of chemical compounds. Hundreds and thousands of assays are available from research organizations to help take your projects forward without much expense or waste of time.
Most pharmaceutical are now using an evidence-based approach towards drug responsiveness based on genetics. Many have their own research labs while others outsource the work to more professional organizations that specialize in assays. You can get both in vitro and in vivo contract research services. These contract research organizations follow FDA guidelines for LC-MS/MS method development and validation. The CRO offers a wide range of ADME services for IND/NDA, vivarium and have highly qualified scientists and technicians who work on client projects. You can get cell-based assays, protein expression and purification, ligand binding assays, biomarker assays and more.
CROs also provide bio-analytical services. You can get help with analysis of rapid screening methods, method development and validation, ocular PK, pro-drug and metabolite PK. Drug discovery helps eliminate the use of multiple drugs. The science is moving forward in the right direction with the help of research labs. Studying how the body absorbs the drug candidate helps create more effective compounds.
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